Prognosis of tongue squamous cell carcinoma associated with individual surgical margin and pathological features
조성지, Sodnom-Ish Buyanbileg, 어미영, 이주영, 권익재, 명훈, 윤혜정, 김성민,
소속 상세정보
조성지 ( Cho Seong-Ji ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
( Sodnom-Ish Buyanbileg ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
어미영 ( Eo Mi-Young ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
이주영 ( Lee Ju-Young ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
권익재 ( Kwon Ik-Jae ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
명훈 ( Myoung Hoon ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
윤혜정 ( Yoon Hye-Jung ) - Seoul National University School of Dentistry Department of Oral Pathology
김성민 ( Kim Soung-Min ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
The specific muscular structure of the tongue greatly affects margin shrinkage and tumor invasion, making the optimal surgical margin controversial. This study investigated surgical margin correlated prognosis of TSCC (tongue squamous cell carcinoma) according to margin location and its value, and the histopathologic factors which are suggestive of tumor invasion. And we would like to propose defining of the surgical margin for TSCC via prognosis according to location and margin values. We reviewed 45 patients diagnosed with TSCC who visited Seoul National University Dental Hospital (SNUDH) (Seoul, Republic of Korea) from 2010 to 2019, who were managed by a single surgical team. Patient clinical and pathological data of patients were retrospectively reviewed, and in 36 out of 45 patients, the pathologic parameters including the worst pattern of invasion (WPOI) and tumor budding were investigated via diagnostic histopathology slide reading. When standardized with as 0.25 cm anterior margins, as 0.35 cm deep margin, there was no significant difference in disease specific survival (DSS) or loco-regional recurrence-free survival (LRFS). Additionally, there was a non-significant difference in DSS and LRFS at the nearest margin of 0.35 cm (PDSS=0.276, PLRFS=0.162). Aggressive WPOI and high tumor budding showed lower survival and recurrence-free survival, and there were significant differences in close margin and involved margin frequencies. In TSCC, the value and location of the surgical margin did not have a significant relationship with prognosis, but WPOI and tumor budding suggesting the pattern of muscle invasion affected survival and recurrence-free survival. WPOI and tumor budding should be considered when setting an optimal surgical margin.
키워드
Oral tongue squamous cell carcinoma; Surgical margin; Worst pattern of invasion; Tumor budding
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